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| Reactivity: | Human, Mouse |
| Applications: | WB, IF/IC, ELISA |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Polyclonal antibody |
| Gene Name: | ADAM metallopeptidase domain 10 |
| Gene Symbol: | ADAM10 |
| Synonyms: | RAK; kuz; AD10; AD18; MADM; CD156c; CDw156; HsT18717; ADAM10 |
| Gene ID: | 102 |
| UniProt ID: | O14672 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 218-433 of human ADAM10 (NP_001101.1). |
| Dilution: | WB 1:500-1:1000; IF/IC 1:50-1:200 |
| Purification Method: | Affinity purification |
| Concentration: | 0.62 mg/ml |
| Buffer: | PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-ADAM10 antibody |
Background
Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Alternate splicing results in multiple transcript variants encoding different proteins that may undergo similar processing.
Images
 | Western blot analysis of lysates from RAW264.7 cells, using ADAM10 Rabbit pAb (A10438) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 20s. |
 | Immunofluorescence analysis of HeLa cells using ADAM10 Rabbit pAb (A10438) at dilution of 1:100. Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (AS007) at 1:500 dilution. Blue: DAPI for nuclear staining. |
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