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| Reactivity: | Human, Mouse |
| Applications: | IF/IC, ELISA |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Polyclonal antibody |
| Gene Name: | bone morphogenetic protein 6 |
| Gene Symbol: | BMP6 |
| Synonyms: | IO; VGR; VGR1; BMP6 |
| Gene ID: | 654 |
| UniProt ID: | P22004 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 375-513 of human BMP6 (NP_001709.1). |
| Dilution: | IF/IC 1:100-1:500 |
| Purification Method: | Affinity purification |
| Concentration: | 2.19 mg/ml |
| Buffer: | Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
| Documents: | Manual-BMP6 antibody |
Background
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Differential expression of this gene may be associated with progression of breast and prostate cancer. Mutations in this gene may be associated with iron overload in human patients.
Images
 | Immunofluorescence analysis of U2OS cells using BMP6 Rabbit pAb (A15648) at dilution of 1:100. Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (AS007) at 1:500 dilution. Blue: DAPI for nuclear staining. |
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