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| Reactivity: | Human, Mouse, Rat |
| Applications: | WB, IHC, IF/IC, ELISA |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal antibody |
| Gene Name: | C-C motif chemokine receptor 7 |
| Gene Symbol: | CCR7 |
| Synonyms: | BLR2; EBI1; CCR-7; CD197; CDw197; CMKBR7; CC-CKR-7; CCR7 |
| Gene ID: | 1236 |
| UniProt ID: | P32248 |
| Clone ID: | 5U7S5 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CCR7 (P32248). |
| Dilution: | WB 1:1000-1:6000; IHC 1:50-1:200; IF/IC 1:100-1:400 |
| Purification Method: | Affinity purification |
| Concentration: | 0.75 mg/mL |
| Buffer: | Buffer:PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-CCR7 antibody |
Background
The protein encoded by this gene is a member of the G protein-coupled receptor family.This receptor was identified as a gene induced by the Epstein-Barr virus (EBV),and is thought to be a mediator of EBV effects on B lymphocytes.This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes.It has been shown to control the migration of memory T cells to inflamed tissues,as well as stimulate dendritic cell maturation.The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor.Signals mediated by this receptor regulate T cell homeostasis in lymph nodes,and may also function in the activation and polarization of T cells,and in chronic inflammation pathogenesis.Alternative splicing of this gene results in multiple transcript variants.
Images
 | Western blot analysis of various lysates using CCR7 Rabbit mAb (A0121) at 1：1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
 | Immunohistochemistry analysis of paraffin-embedded Rat testis using CCR7 Rabbit mAb (A0121) at dilution of 1:100 (40x lens). Microwave antigen retrieval performed with 0.01M PBS Buffer (pH 7.2) prior to IHC staining. |
 | Immunohistochemistry analysis of paraffin-embedded Human esophageal using CCR7 Rabbit mAb (A0121) at dilution of 1:100 (40x lens). Microwave antigen retrieval performed with 0.01M PBS Buffer (pH 7.2) prior to IHC staining. |
 | Confocal imaging of Human spleen using CCR7 Rabbit mAb (A0121,dilution 1:100)(Red). DAPI was used for nuclear staining (blue). Objective: 60x. |
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