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| Reactivity: | Human |
| Applications: | WB, ELISA |
| Host Species: | Rabbit |
| Clonality: | Polyclonal antibody |
| Gene Name: | exosome component 1 |
| Gene Symbol: | EXOSC1 |
| Synonyms: | p13; CSL4; SKI4; Csl4p; PCH1F; Ski4p; CGI-108; EXOSC1 |
| Gene ID: | 51013 |
| UniProt ID: | Q9Y3B2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-195 of human EXOSC1 (NP_057130.1). |
| Dilution: | WB 1:500-1:2000 |
| Purification Method: | Affinity purification |
| Concentration: | 1.48 mg/ml |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-EXOSC1 antibody |
Background
This gene encodes a core component of the exosome. The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening. The association of this protein with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46. Alternative splicing of this gene results in multiple transcript variants.
Images
 | Western blot analysis of various lysates using EXOSC1 Rabbit pAb (A10302) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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