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| Reactivity: | Human, Mouse, Rat |
| Applications: | WB, ELISA |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal antibody |
| Gene Name: | interferon alpha and beta receptor subunit 1 |
| Gene Symbol: | IFNAR1 |
| Synonyms: | AVP; IFRC; IFNAR; IFNBR; IMD106; IFN-alpha-REC; IFNAR1 |
| Gene ID: | 3454 |
| UniProt ID: | P17181 |
| Clone ID: | 6N3L3 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 458-557 of human IFNAR1 (P17181). |
| Dilution: | WB 1:1000-1:2000 |
| Purification Method: | Affinity purification |
| Concentration: | 0.4 mg/mL |
| Buffer: | PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-IFNAR1 antibody |
Background
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The protein belongs to the type II cytokine receptor family and functions as an antiviral factor.
Images
 | Western blot analysis of lysates from HeLa cells using IFNAR1 Rabbit mAb (A0575) at 1:1000 dilution incubated overnight at 4℃. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25 μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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