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| Reactivity: | Human, Mouse |
| Applications: | WB, IP, ELISA |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Polyclonal antibody |
| Gene Name: | junction plakoglobin |
| Gene Symbol: | JUP |
| Synonyms: | PG; DP3; PDGB; PKGB; CTNNG; DPIII; γ-Catenin |
| Gene ID: | 3728 |
| UniProt ID: | P14923 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human γ-Catenin (NP_002221.1). |
| Dilution: | WB 1:500-1:2000 |
| Purification Method: | Affinity purification |
| Concentration: | 0.25 mg/mL |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-JUP antibody |
Background
This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described.
Images
 | Western blot analysis of various lysates using γ-Catenin Rabbit pAb (A0963) at 1:500 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). |
 | Immunoprecipitation analysis of 200 μg extracts of MCF-7 cells, using 3 μg γ-Catenin antibody (A0963). Western blot was performed from the immunoprecipitate using γ-Catenin antibody (A0963) at a dilution of 1:1000. |
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