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| Reactivity: | Human, Mouse, Rat |
| Applications: | WB, IF/IC, IP, ELISA |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Polyclonal antibody |
| Gene Name: | prolyl 4-hydroxylase subunit beta |
| Gene Symbol: | P4HB |
| Synonyms: | DSI; GIT; PDI; PHDB; PDIA1; PO4DB; PO4HB; PROHB; CLCRP1; ERBA2L; P4Hbeta; P4HB |
| Gene ID: | 5034 |
| UniProt ID: | P07237 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 329-508 of human P4HB (NP_000909.2). |
| Dilution: | WB 1:500-1:2000; IF/IC 1:20-1:100 |
| Purification Method: | Affinity purification |
| Concentration: | 0.43 mg/ml |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-P4HB antibody |
Background
This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex.
Images
 | Confocal immunofluorescence analysis of U-2OS cells using P4HB Rabbit pAb (A0692) at dilution of 1:400. Blue: DAPI for nuclear staining. |
 | Immunoprecipitation analysis of 200 μg extracts of SW620 cells using 3 μg P4HB antibody (A0692). Western blot was performed from the immunoprecipitate using P4HB antibody (A0692) at a dilution of 1:500. |
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