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| Reactivity: | Human, Mouse, Rat, Monkey |
| Applications: | WB, IHC, ELISA |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Polyclonal antibody |
| Gene Name: | prohibitin 1 |
| Gene Symbol: | PHB1 |
| Synonyms: | PHB; HEL-215; HEL-S-54e; Prohibitin |
| Gene ID: | 5245 |
| UniProt ID: | P35232 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 73-272 of human Prohibitin (NP_002625.1). |
| Dilution: | WB 1:500-1:2000; IHC 1:100-1:500 |
| Purification Method: | Affinity purification |
| Concentration: | 6.84 mg/ml |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
| Documents: | Manual-PHB1 antibody |
Background
This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.
Images
 | Western blot analysis of various lysates using Prohibitin Rabbit pAb (A13526) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunohistochemistry analysis of paraffin-embedded Human breast cancer using Prohibitin Rabbit pAb (A13526) at dilution of 1:500 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate Bufferr (pH 6.0) prior to IHC staining. |
 | Immunohistochemistry analysis of paraffin-embedded Human lung cancer using Prohibitin Rabbit pAb (A13526) at dilution of 1:500 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate Bufferr (pH 6.0) prior to IHC staining. |
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