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| Reactivity: | Human |
| Applications: | WB, ELISA |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Polyclonal antibody |
| Gene Name: | solute carrier organic anion transporter family member 1B1 |
| Gene Symbol: | SLCO1B1 |
| Synonyms: | LST1; HBLRR; LST-1; OATP2; OATPC; OATP-C; OATP1B1; SLC21A6; SLCO1B1 |
| Gene ID: | 10599 |
| UniProt ID: | Q9Y6L6 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 597-691 of human SLCO1B1 (NP_006437.3). |
| Dilution: | WB 1:500-1:2000 |
| Purification Method: | Affinity purification |
| Concentration: | 0.86 mg/ml |
| Buffer: | Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
| Documents: | Manual-SLCO1B1 antibody |
Background
This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function.
Images
 | Western blot analysis of various lysates using SLCO1B1 Rabbit pAb (A15783) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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