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Product Category:
Human Adenovirus Type5 (dE1/E3) expressing ADAM17 gene under CMV promoter.
Description:
ADAM Metallopeptidase Domain 17, pre-made adenovirus, ready to ship and ready to use format.
Gene Name:
ADAM Metallopeptidase Domain 17
ACCN:
BC062687
Gene ID:
6868
GI Number:
BC062687
Fusion Tag:
No
Promoter:
CMV
Storage Buffer:
DMEM with 2.5% BSA, 2.5% glycerol
Background:
ADAM17 (disintegrin and metalloproteinase domain-containing protein 17) cleaves the membrane bound precusor of TNF-alpha to its mature soluble form. ADAM 17 is responsbile for the proteolytical release of soluble JAM3 from endothelial cells surface and the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1, and the amyloid precursor protein. It acts as an activator of the Notch pathway by mediating cleavage of Notch and generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Mutations in the gene can result in inflammatory skin and bowel disease, neonatal 1.
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