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| Product Category: | Human Adenovirus Type5 (dE1/E3) expressing ADAM17 gene under CMV promoter. |
| Description: | ADAM Metallopeptidase Domain 17, pre-made adenovirus, ready to ship and ready to use format. |
| Gene: | ADAM Metallopeptidase Domain 17 |
| NCBI Acc. #: | BC062687 |
| Gene ID: | 6868 |
| GI Number: | BC062687 |
| Fusion Tag: | No |
| Promoter: | CMV |
| Storage Buffer: | DMEM with 2.5% BSA, 2.5% glycerol |
| Background: | ADAM17 (disintegrin and metalloproteinase domain-containing protein 17) cleaves the membrane bound precusor of TNF-alpha to its mature soluble form. ADAM 17 is responsbile for the proteolytical release of soluble JAM3 from endothelial cells surface and the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1, and the amyloid precursor protein. It acts as an activator of the Notch pathway by mediating cleavage of Notch and generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Mutations in the gene can result in inflammatory skin and bowel disease, neonatal 1. |
| Documents: | Please contact us to request the manual |
