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| Product Category: | Human Adenovirus Type5 (dE1/E3) expressing Dual-specificity Tyrosine-(Y)-phosphorylation Regulated Kinase 2 (DYRK2). |
| Description: | Dual-specificity Tyrosine-(Y)-phosphorylation Regulated Kinase 2, pre-made adenovirus, ready to ship and ready to use format. |
| Gene: | Dual-specificity Tyrosine-(Y)-phosphorylation Regulated Kinase 2 |
| NCBI Acc. #: | BC006375 |
| Gene ID: | 8445 |
| GI Number: | 13623532 |
| Fusion Tag: | C-terminus V5 epitope tag |
| Promoter: | CMV |
| Titer: | 1x1010~1x1011 PFU/ml |
| Storage Buffer: | DMEM with 2.5% BSA, 2.5% glycerol |
| Background: | DYRK2, or dual specificity tyrosine-phosphorylation-regulated kinase 2, has a role in the regulation of cellular growth and/or development. In response to DNA damage, DYRK2 regulates p53 phosphorylation on Ser-46 to induce apoptosis. DYRK2 has been proposed to inactivate GYS1 by phosphorylation at Ser-641, and potentially a second phosphorylation site, thus regulating glycogen synthesis. DYRK2 also phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3, and may play a more general role in the priming of GSK3 substrates. |
| Documents: | Please contact us to request the manual |
