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| Product Category: | Human Adenovirus Type5 (dE1/E3) expressing human Glucokinase (hexokinase 4, Maturity Onset Diabetes Of The Young 2) under a CMV promoter. |
| Description: | Glucokinase (hexokinase 4, Maturity Onset Diabetes Of The Young 2), pre-packaged adenovirus, ready to ship and ready to use format. |
| Gene: | Glucokinase (hexokinase 4, Maturity Onset Diabetes Of The Young 2) |
| NCBI Acc. #: | BC001890 |
| Gene ID: | 2645 |
| GI Number: | 12804882 |
| Fusion Tag: | No |
| Promoter: | CMV |
| Titer: | 1x1010~1x1011 PFU/ml |
| Storage Buffer: | DMEM with 2.5% BSA, 2.5% glycerol |
| Background: | Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Alternative splicing of this gene results in three tissue-specific forms of glucokinase （GCK）, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). |
| Documents: | Please contact us to request the manual |
