Adenovirus TP53RK (200 µl)

Adenovirus TP53RK (200 µl)

Cat. #: M1057
Availability: In Stock
$685.00
-+
Product Category: 
Human Adenovirus Type5 (dE1/E3) expressing TP53 Regulating Kinase (dominant negative format) under a CMV promoter.
Description: TP53 Regulating Kinase (kinase dead or dominant negative), premade adenovirus, ready to ship and ready to use format.
Gene: TP53 Regulating Kinase (kinase dead or dominant negative)
NCBI Acc. #: BC009727
Gene ID: 112858
GI Number: 16307276
Fusion Tag: C-terminus 6xHN tag
Promoter: CMV
Mutation: G217A, A218T, E73M
Titer: 1E+10~1E+11 PFU/ml
Storage Buffer: DMEM with 2.5% BSA, 2.5% glycerol
Background:   Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:27903914). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:27903914). TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP. Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (PubMed:11546806).
Documents: Please contact us to request the manual

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