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ABflo® 488 Rabbit anti-Human GP6/GPVI mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 488. Ex:491nm. Em:516nm. |
| Gene Name: | glycoprotein VI platelet |
| Gene Symbol: | GP6 |
| Synonyms: | GPIV; GPVI; BDPLT11 |
| Gene ID: | 51206 |
| UniProt ID: | Q9HCN6 |
| Clone ID: | 6M1C6 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-267 of human GP6/GPVI (NP_057447.5). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.01 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-GP6 antibody |
Background
This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Images
 | Flow cytometry: 1×10^6 MOLT-4 cells (negative control,left) and HEL cells (right) were surface-stained with ABflo® 488 Rabbit anti-Human GP6/GPVI mAb (A24103,5 μl/Test,orange line) or ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 HEL cells were surface-stained with ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,left) or ABflo® 488 Rabbit anti-Human GP6/GPVI mAb (A24103,5 μl/Test,right). |
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