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ABflo® 488 Rabbit anti-Mouse CD107b mAb (100 T)
| Reactivity: | Mouse |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 488. Ex:491nm. Em:516nm. |
| Gene Name: | lysosomal-associated membrane protein 2 |
| Gene Symbol: | Lamp2 |
| Synonyms: | Mac3; LGP-B; CD107b; Lamp-2; Lamp II; Lamp-2a; Lamp-2b; Lamp-2c |
| Gene ID: | 16784 |
| UniProt ID: | P17047 |
| Clone ID: | 6C7H4 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-189 of mouse CD107b (NP_001017959.1). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-Lamp2 antibody |
Background
Enables protein domain specific binding activity. Involved in several processes, including autophagosome maturation; protein stabilization; and protein targeting to lysosome involved in chaperone-mediated autophagy. Acts upstream of or within muscle cell cellular homeostasis. Located in late endosome membrane; lysosomal membrane; and phagocytic vesicle membrane. Is integral component of autophagosome membrane. Is expressed in central nervous system; egg cylinder; lung; and retina. Used to study Danon disease. Human ortholog(s) of this gene implicated in Danon disease and hypertrophic cardiomyopathy. Orthologous to human LAMP2 (lysosomal associated membrane protein 2).
Images
 | Flow cytometry: 1×10^6 NIH/3T3-CD107b-shRNA4 cells (negative control,left) and NIH/3T3-scramble cells (right) were surface-stained with ABflo® 488 Rabbit anti-Mouse CD107b mAb (A25930,5 μl/Test,orange line) or ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 NIH/3T3-scramble cells were surface-stained with ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,left) or ABflo® 488 Rabbit anti-Mouse CD107b mAb (A25930,5 μl/Test,right). |
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