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ABflo® 488 Rabbit anti-Mouse RANK/CD265 mAb (100 T)
| Reactivity: | Mouse |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 488. Ex:491nm. Em:516nm. |
| Gene Name: | tumor necrosis factor receptor superfamily, member 11a, NFKB activator |
| Gene Symbol: | Tnfrsf11a |
| Synonyms: | OFE; ODFR; Rank; Ly109; mRANK; TRANCE-R |
| Gene ID: | 21934 |
| UniProt ID: | O35305 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 31-213 of mouse RANK/CD265 (NP_033425.3). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/ml |
| Buffer: | PBS with 0.09% Sodium azide,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-Tnfrsf11a antibody |
Background
Enables tumor necrosis factor-activated receptor activity. Involved in several processes, including circadian temperature homeostasis; positive regulation of fever generation by positive regulation of prostaglandin secretion; and tumor necrosis factor-mediated signaling pathway. Acts upstream of or within several processes, including hematopoietic or lymphoid organ development; mammary gland alveolus development; and positive regulation of bone resorption. Located in cell surface. Is expressed in bladder and lymphatic system. Human ortholog(s) of this gene implicated in Paget's disease of bone; autosomal recessive osteopetrosis 7; bone development disease; familial expansile osteolysis; and osteoporosis. Orthologous to human TNFRSF11A (TNF receptor superfamily member 11a).
Images
 | Flow cytometry: 1×10^6 293T cells (negative control,left) and 293T cells (Transfection,right) were surface-stained with ABflo® 488 Rabbit anti-Mouse RANK/CD265 mAb (A27178,5 μl/Test,orange line) or ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 293T (Transfection) cells were surface-stained with ABflo® 488 Rabbit IgG isotype control (A22069,5 μl/Test,left) or ABflo® 488 Rabbit anti-Mouse RANK/CD265 mAb (A27178,5 μl/Test,right). |
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