ABflo® 500 Mouse anti-Human CD11b mAb (100 T)

Background

This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene.

Images

	Flow cytometry: 1×10^6 Jurkat cells (negative control,left) and Human PBMC (right) were surface-stained with ABflo® 500 Mouse anti-Human CD11b mAb (A27474,5 μl/Test,orange line) or ABflo® 500 Mouse IgG1 isotype control (5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line).
	Flow cytometry: 1×10^6 Human PBMC were surface-stained with ABflo® 500 Mouse IgG1 isotype control (5 μl/Test,left) or ABflo® 500 Mouse anti-Human CD11b mAb (A27474,5 μl/Test,right).
	Flow cytometry: 1×10^6 Human PBMC were surface-stained with PE Rabbit anti-Human CD14 mAb (A25938,5 μl/Test) and ABflo® 500 Mouse IgG1 isotype control (5 μl/Test,left) or ABflo® 500 Mouse anti-Human CD11b mAb (A27474,5 μl/Test,right). Cells in the Monocyte gate were used for analysis.

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