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ABflo® 594 Rabbit anti-Human CD27 mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 594. Ex:588nm. Em:604nm. |
| Gene Name: | CD27 molecule |
| Gene Symbol: | CD27 |
| Synonyms: | T14; S152; Tp55; TNFRSF7; S152. LPFS2 |
| Gene ID: | 939 |
| UniProt ID: | P26842 |
| Clone ID: | 2K1J4 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-192 of human CD27 (NP_001233.2). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-CD27 Antibody |
Background
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.
Images
 | Flow cytometry: 1×10^6 HEL cells (negative control,left) and Daudi cells (right) were surface-stained with ABflo® 594 Rabbit anti-Human CD27 mAb (A25110,5 μl/Test,orange line) or ABflo® 594 Rabbit IgG isotype control (A23821,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 Daudi cells were surface-stained with ABflo® 594 Rabbit IgG isotype control (A23821,5 μl/Test,left) or ABflo® 594 Rabbit anti-Human CD27 mAb (A25110,5 μl/Test,right). |
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