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ABflo® 594 Rabbit anti-Human Claudin18.2 mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 594. Ex:588nm. Em:604nm. |
| Gene Name: | claudin 18 |
| Gene Symbol: | CLDN18 |
| Synonyms: | SFTA5; SFTPJ |
| Gene ID: | 51208 |
| UniProt ID: | P56856-2 |
| Clone ID: | 5J9Y2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-261 of human Claudin18.2(NP_001002026.1). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.01 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-CLDN18 antibody |
Background
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.
Images
 | Flow cytometry:1×10^6 CHO cells(negative control,left) and CHO(Transfection,right) cells were surface-stained with ABflo® 594 Rabbit anti-Human Claudin18.2 mAb(A23393,5 μl/Test,orange line) or ABflo® 594 Rabbit IgG isotype control (A23821,5 μl/Test,blue line).Non-fluorescently stained cells was used as blank control (red line). |
 | Flow cytometry:1×10^6 CHO(Transfection) cells were surface-stained with ABflo® 594 Rabbit IgG isotype control (A23821,5 μl/Test,left) or ABflo® 594 Rabbit anti-Human Claudin18.2 mAb(A23393,5 μl/Test,right). |
 | Flow cytometry:1×10^6 NUGC4 cells were surface-stained with ABflo® 594 Rabbit IgG isotype control (A23821,5 μl/Test,left) or ABflo® 594 Rabbit anti-Human Claudin18.2 mAb(A23393,5 μl/Test,right). |
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