ABflo® 594 Rabbit anti-Human LIFR/CD118 mAb (100 T)

Background

This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding two different isoforms have been found for this gene.

Images

	Flow cytometry: 1×10^6 REH cells (negative control,left) and HeLa cells (right) were surface-stained with ABflo® 594 Rabbit anti-Human LIFR/CD118 mAb (A25078,5 μl/test,orange line) or ABflo® 594 Rabbit IgG isotype control (A23821,5 μl/test,blue line). Non-fluorescently stained cells were used as blank control (red line).
	Flow cytometry: 1×10^6 HeLa cells were surface-stained with ABflo® 594 Rabbit IgG isotype control (A23821,5 μl/test,left) or ABflo® 594 Rabbit anti-Human LIFR/CD118 mAb (A25078,5 μl/test,right).

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