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ABflo® 647 Rabbit anti-Human CD62E/E-Selectin mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 647. Ex:648nm. Em:664nm. |
| Gene Name: | selectin E |
| Gene Symbol: | SELE |
| Synonyms: | ELAM; ESEL; CD62E; ELAM1; LECAM2; selectin-e |
| Gene ID: | 6401 |
| UniProt ID: | P16581 |
| Clone ID: | 9Q5W4 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-230 of human CD62E/E-Selectin (NP_000441.2). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-SELE Antibody |
Background
The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis.
Images
 | Flow cytometry:1×10^6 HUVEC cells (negative control, Left) and HUVEC cells(treated with TNF-α,Right) were surface-stained with ABflo® 647 Rabbit anti-Human CD62E/E-Selectin mAb(A24309,5 μl/Test,orange line) or ABflo® 647 Rabbit IgG isotype control (A22070,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry:1×10^6 HUVEC cells(treated with TNF-α,Right) were surface-stained with ABflo® 647 Rabbit IgG isotype control (A22070,5 μl/Test,left) or ABflo® 647 Rabbit anti-Human CD62E/E-Selectin mAb(A24309,5 μl/Test,right). |
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