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ABflo® 647 Rabbit anti-Human/Mouse CD276/B7-H3 mAb (100 T)
| Reactivity: | Human, Mouse |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 647. Ex:648nm. Em:664nm. |
| Gene Name: | CD276 molecule |
| Gene Symbol: | CD276 |
| Synonyms: | B7H3; B7-H3; B7RP-2; 4Ig-B7-H3 |
| Gene ID: | 80381 |
| UniProt ID: | Q5ZPR3-2 |
| Clone ID: | 4C0W1 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-245 of human CD276 mAb (NP_079516.1). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.01 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-CD276 antibody |
Background
The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Images
 | Flow cytometry:1×10^6 Jurkat cells (negative control,left) and PC-3 cells (right) were surface-stained with ABflo® 647 Rabbit anti-Human CD276/B7-H3 mAb(A22157,5 μl/Test,orange line) or ABflo® 647 Rabbit IgG isotype control (A22070,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 C2C12 cells were surface-stained with ABflo® 647 Rabbit anti-Human/Mouse CD276/B7-H3 mAb(A22157,5 μl/Test,orange line) or ABflo® 647 Rabbit IgG isotype control (A22070,5 μl/Test,blue line).Non-fluorescently stained C2C12 cells was used as blank control (red line). |
 | Flow cytometry:1×10^6 C2C12 cells were surface-stained with ABflo® 647 Rabbit IgG isotype control (A22070,5 μl/Test,left) or ABflo® 647 Rabbit anti-Human/Mouse CD276/B7-H3 mAb(A22157,5 μl/Test,right). |
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