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ABflo® 647 Rabbit anti-Mouse CD88/C5aR mAb (100 T)
| Reactivity: | Mouse |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 647. Ex:648nm. Em:664nm. |
| Gene Name: | complement component 5a receptor 1 |
| Gene Symbol: | C5ar1 |
| Synonyms: | C5aR; C5r1; Cd88; D7Msu1 |
| Gene ID: | 12273 |
| UniProt ID: | P30993 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-37 of mouse CD88/C5aR (NP_031603.2). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/ml |
| Buffer: | PBS with 0.09% Sodium azide,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-C5ar1 Antibody |
Background
Enables complement component C5a receptor activity. Involved in several processes, including astrocyte activation; positive regulation of vascular endothelial growth factor production; and regulation of granulocyte chemotaxis. Acts upstream of or within defense response to Gram-positive bacterium; neutrophil chemotaxis; and response to peptidoglycan. Predicted to be located in several cellular components, including apical part of cell; basolateral plasma membrane; and cell surface. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; liver; neural ectoderm; and sensory organ. Orthologous to several human genes including OPRPN (opiorphin prepropeptide).
Images
 | Flow cytometry: 1×10^6 C57BL/6 mouse splenocytes (negative control,left) and C57BL/6 mouse bone marrow cells (right) were surface-stained with ABflo® 647 Rabbit anti-Mouse CD88/C5aR mAb (A26711,5 μl/Test,orange line) or ABflo® 647 Rabbit IgG isotype control (A22070,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 C57BL/6 mouse bone marrow cells were surface-stained with ABflo® 647 Rabbit IgG isotype control (A22070,5 μl/Test,left) or ABflo® 647 Rabbit anti-Mouse CD88/C5aR mAb (A26711,5 μl/Test,right). |
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