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ABflo® 700 Mouse anti-Human CD3 mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Mouse |
| Isotype: | IgG2a |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 700. Ex:690nm. Em:713nm. |
| Gene Name: | CD3 epsilon subunit of T-cell receptor complex |
| Gene Symbol: | CD3E |
| Synonyms: | T3E; TCRE; IMD18; CD3epsilon |
| Gene ID: | 916 |
| UniProt ID: | P07766 |
| Clone ID: | 1Q3B2 |
| Immunogen: | Recombinant protein of human CD3. |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.01 mg/mL |
| Buffer: | PBS with 0.03% proclin300,pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-CD3E Antibody |
Background
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.
Images
 | Flow cytometry: 1×10^6 Human PBMC were surface-stained with ABflo® 700 Mouse anti-Human CD3 mAb (A24943,5 μl/Test). |
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