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APC Mouse anti-Human CD11b mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Mouse |
| Isotype: | IgG1, κ |
| Clonality: | Monoclonal Antibody |
| Conjugation: | APC. Ex:650nm. Em:660nm. |
| Gene Name: | integrin subunit alpha M |
| Gene Symbol: | ITGAM |
| Synonyms: | CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6 |
| Gene ID: | 3684 |
| UniProt ID: | P11215 |
| Immunogen: | A synthesized peptide derived from human CD11b. |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/ml |
| Buffer: | PBS with 0.09% Sodium azide,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-ITGAM Antibody |
Background
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene.
Images
 | Flow cytometry: 1×10^6 Human peripheral blood granulocytes were surface-stained with APC Mouse anti-Human CD11b mAb (A27195,5 μl/Test,orange line) or APC Mouse IgG1 (5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 Human peripheral blood granulocytes were surface-stained with APC Mouse IgG1 isotype control (5 μl/Test,left) or APC Mouse anti-Human CD11b mAb (A27195,5 μl/Test,right). |
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