PE Rabbit anti-Human CD1c mAb (100 T)

Background

This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their full-length nature is not known.

Images

	Flow cytometry: 1×10^6 K-562 cells (negative control,left) and MOLT-4 cells (right) were surface-stained with PE Rabbit anti-Human CD1c mAb (A26838,5 μl/Test,orange line) or PE Rabbit IgG isotype control (A24172,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line).
	Flow cytometry: 1×10^6 MOLT-4 cells were surface-stained with PE Rabbit IgG isotype control (A24172,5 μl/Test,left) or PE Rabbit anti-Human CD1c mAb (A26838,5 μl/Test,right).
	Flow cytometry:1×10^6 Human PBMC were surface-stained with APC Mouse anti-Human CD19 mAb (5 μl/Test) and PE Rabbit IgG isotype control (A24172,5 μl/Test,left) or PE Rabbit anti-Human CD1c mAb (A26838,5 μl/Test,right).Cells in the lymphocytes gate were used for analysis.

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