PE Rabbit anti-Human CD87/PLAUR mAb (100 T)

Background

This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined.

Images

	Flow cytometry: 1×10^6 Daudi cells (negative control,left) and U-87 MG cells (right) were surface-stained with PE Rabbit anti-Human CD87/PLAUR mAb (A26640,5 μl/Test,orange line) or PE Rabbit IgG isotype control (A24172,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line).
	1×10^6 Human PBMC were surface-stained with PE Rabbit anti-Human CD87/PLAUR mAb (A26640,5 μl/Test,orange line) or PE Rabbit IgG isotype control (A24172,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). Cells in the monocytes gate were used for analysis.
	Flow cytometry: 1×10^6 U-87 MG cells were surface-stained with PE Rabbit IgG isotype control (A24172,5 μl/Test,left) or PE Rabbit anti-Human CD87/PLAUR mAb (A26640,5 μl/Test,right).

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