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PE Rabbit anti-Human Complement C3 mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | PE. Ex:565nm. Em:574nm. |
| Gene Name: | complement C3 |
| Gene Symbol: | C3 |
| Synonyms: | ASP; C3a; C3b; AHUS5; ARMD9; CPAMD1; HEL-S-62p |
| Gene ID: | 718 |
| UniProt ID: | P01024 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1498-1663 of human Complement C3 (NP_000055.2). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/ml |
| Buffer: | PBS with 0.09% Sodium azide,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-C3 Antibody |
Background
Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients.
Images
 | Flow cytometry: 1×10^6 Jurkat cells (negative control,left) and HepG2 cells (right) were surface-stained with PE Rabbit anti-Human Complement C3 mAb (A27173,5 μl/Test,orange line) or PE Rabbit IgG isotype control (A24172,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
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