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PE Rabbit anti-Human IL-17RA/CD217 mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | PE. Ex:565nm. Em:574nm. |
| Gene Name: | interleukin 17 receptor A |
| Gene Symbol: | IL17RA |
| Synonyms: | CD217; IL17R; IMD51; CANDF5; CDw217; IL-17RA; hIL-17R |
| Gene ID: | 23765 |
| UniProt ID: | Q96F46 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 33-320 of human IL-17RA/CD217 (NP_055154.3). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/ml |
| Buffer: | PBS with 0.09% Sodium azide,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-IL17RA antibody |
Background
Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms.
Images
 | Flow cytometry: 1×10^6 HEL cells (negative control,left) and HL-60 cells (right) were surface-stained with PE Rabbit anti-Human IL-17RA/CD217 mAb (A27411,5 μl/Test,orange line) or PE Rabbit IgG isotype control (A24172,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 Human PBMC were surface-stained with PE Rabbit anti-Human IL-17RA/CD217 mAb (A27411,5 μl/Test,orange line) or PE Rabbit IgG isotype control (A24172,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). Cells in the Monocyte gate were used for analysis. |
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