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PE Rabbit anti-Human Siglec-8 mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | PE. Ex:565nm. Em:574nm. |
| Gene Name: | sialic acid binding Ig like lectin 8 |
| Gene Symbol: | SIGLEC8 |
| Synonyms: | SAF2; SIGLEC-8; SIGLEC8L |
| Gene ID: | 27181 |
| UniProt ID: | Q9NYZ4 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 17-363 of human Siglec-8(NP_055257.2). |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/ml |
| Buffer: | PBS with 0.09% Sodium azide,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-SIGLEC8 antibody |
Background
Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).
Images
 | Flow cytometry: 1×10^6 293F cells (negative control,left) and 293F (Transfection,right) cells were surface-stained with PE Rabbit anti-Human Siglec-8 mAb (A26516,5 μl/Test,orange line) or PE Rabbit IgG isotype control (A24172,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 293F (Transfection) cells were surface-stained with PE Rabbit IgG isotype control (A24172,5 μl/Test,left) or PE Rabbit anti-Human Siglec-8 mAb (A26516,5 μl/Test,right). |
 | Flow cytometry: 1×10^6 Human peripheral blood granulocytes were surface-stained with PE Rabbit IgG isotype control (A24172,5 μl/Test,left) or PE Rabbit anti-Human Siglec-8 mAb (A26516,5 μl/Test,right). |
 | Flow cytometry:1×10^6 Human peripheral blood granulocytes were surface-stained with PE Rabbit anti-Human Siglec-8 mAb (A26516,5 μl/Test) and PE Rabbit IgG isotype control (A24172,5 μl/Test,left) or APC Mouse anti-Human CCR3 mAb (5 μl/Test,right). |
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