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| Reactivity: | Human, Rat |
| Applications: | WB |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Polyclonal antibody |
| Gene Name: | eukaryotic elongation factor 2 kinase |
| Gene Symbol: | EEF2K |
| Synonyms: | eEF-2K; CaMKIII; HSU93850 |
| Gene ID: | 29904 |
| UniProt ID: | O00418 |
| Immunogen: | A synthesized peptide derived from human EEF2K |
| Dilution: | WB 1:2,500-1:5,000 |
| Purification Method: | Affinity purified |
| Concentration: | Lot dependent |
| Buffer: | PBS with 0.01% thimerosal, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
Background
This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment.
Images
 | Western blotting analysis using anti-Eukaryotic elongation factor 2 kinase antibody (Cat#62828). Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with anti-Eukaryotic elongation factor 2 kinase antibody (Cat#62828, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using FeQ™ ECL Substrate Kit (Cat#226). |
 | Western blotting analysis using anti-Eukaryotic elongation factor 2 kinase antibody (Cat#62828). Eukaryotic elongation factor 2 kinase expression in wild type (WT) and Eukaryotic elongation factor 2 kinase shRNA knockdown (KD) HeLa cells with 30 μg of total cell lysates. β-Tubulin serves as a loading control. The blot was incubated with anti-Eukaryotic elongation factor 2 kinase antibody (Cat#62828, 1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (Cat#201, 1:20,000) respectively. Image was developed using FeQ™ ECL Substrate Kit (Cat#226). |
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