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ABflo® 610 Rabbit anti-Human/Mouse BCL6 mAb (100 T)
| Reactivity: | Human, Mouse |
| Applications: | FC (intra) |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 610. Ex:421nm. Em:612nm. |
| Gene Name: | BCL6 transcription repressor |
| Gene Symbol: | BCL6 |
| Synonyms: | BCL5; LAZ3; BCL6A; ZNF51; ZBTB27 |
| Gene ID: | 604 |
| UniProt ID: | P41182 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 235-350 of human/mouse BCL6 (NP_001124317.1). |
| Dilution: | FC (intra),5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/ml |
| Buffer: | PBS with 0.09% Sodium azide,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-BCL6 Antibody |
Background
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
Images
 | Flow cytometry: 1×10^6 HAP1 cells (Low Expression,left) and Daudi cells (right) were intracellularly-stained with ABflo® 610 Rabbit anti-Human/Mouse BCL6 mAb (A26765,5 μl/Test,orange line) or ABflo® 610 Rabbit IgG isotype control (A25826,5 μl/Test,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 Daudi cells were intracellularly-stained with ABflo® 610 Rabbit IgG isotype control (A25826,5 μl/Test,left) or ABflo® 610 Rabbit anti-Human/Mouse BCL6 mAb (A26765,5 μl/Test,right). |
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