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Recombinant Anti-Bax Rabbit mAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Monoclonal |
| Gene Name: | Apoptosis regulator BAX |
Synonyms: | BAX, BCL2L4, BCL2 associated X protein, BCL2 associated X, apoptosis regulator |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Bax |
Uniprot ID: | Q07813 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Mitochondrion, Cytoplasm |
Predicted MW. / Observed MW. | 21 kDa / 21 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 1000-1: 2000 | lung, liver, kidney |
Background
Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. BAX deficiency leads to lymphoid hyperplasia and male sterility, because of the cessation of sperm production.
Images
| WB analysis of Bax(GB15690). |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |