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| Reactivity: | Human |
| Applications: | WB, ELISA |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Polyclonal antibody |
| Gene Name: | C-X-C motif chemokine ligand 10 |
| Gene Symbol: | CXCL10 |
| Synonyms: | C7; IFI10; INP10; IP-10; crg-2; mob-1; SCYB10; gIP-10; CXCL10/IP-10 |
| Gene ID: | 3627 |
| UniProt ID: | P02778 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-98 of human CXCL10/IP-10 (NP_001556.2). |
| Dilution: | WB 1:500-1:2000 |
| Purification Method: | Affinity purification |
| Concentration: | 0.25 mg/ml |
| Buffer: | PBS with 0.09% Sodium azide, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
| Documents: | Manual-CXCL10 antibody |
Background
This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. This gene may also be a key regulator of the 'cytokine storm' immune response to SARS-CoV-2 infection.
Images
 | Western blot analysis of lysates from HeLa cells, using CXCL10/IP-10 Rabbit pAb (A1457). Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Western blot analysis of lysates from THP-1 cells using CXCL10/IP-10 Rabbit pAb (A1457) at 1:2000 dilution incubated overnight at 4℃. THP-1 cells were treated by IFN-γ (200ng/ml) at 37℃ for 24 hours,LPS (50ng/ml) at 37℃ for 24 hours and BFA (5ug/ml ) at 37℃ for 21 hours. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 30 μg per lane. Blocking buffer: 3 % nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 20s. |
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