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| Reactivity: | H,M,R & M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | EGR1 rabbit polyclonal antibody |
Gene Name: | Early growth response protein 1 |
Synonyms: | EGR1, AT225, G0S30, KROX-24, NGFI-A, TIS8, ZIF-268, ZNF225, Early growth response 1 |
Immunogen: | Recombinant protein corresponding to Mouse EGR1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Cytoplasm |
Predicted MW. | 57 kDa |
Observed MW. | 57 kDa |
Uniprot ID: | P08046, P18146, P08154 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | liver, uterus, testis |
IHC/IF | Mouse, Rat | 1: 500-1: 3000 | brain, lung |
Background
EGR-1 (Early growth response protein 1) is a protein encoded by the EGR1 gene. The protein belongs to the EGR family of Cys2His2-type zinc finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentiation and mitogenesis. Studies suggest this is a tumor suppressor gene. It has a distinct pattern of expression in the brain, and its induction has been shown to be associated with neuronal activity. Several studies suggest it has a role in neuronal plasticity. EGR-1 has also been found to regulate the expression of VAMP2.
Images
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Western blot analysis of EGR1 (GB11853) at dilution of 1: 500 |
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Immunofluorescence of paraffin embedded mouse lung using EGR1 (GB11853) at dilution of 1: 500 (400x lens) |
 | Immunofluorescence of paraffin embedded rat brain using EGR1 (GB11853) at dilution of 1: 500 (400x lens) |
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Immunofluorescence of paraffin embedded rat lung using EGR1 (GB11853) at dilution of 1: 500 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |