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| Reactivity: | M,R & M,R |
| Applications: | WB & IHC |
| Host Species: | Mouse |
| Clonality: | Monoclonal |
| Gene Name: | Neuromodulin |
Synonyms: | GAP43, B-50, PP46, growth associated protein 43 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse GAP43 |
Uniprot ID: | P06837 |
Isotype: | IgG2a,κ |
Purity: | Affinity purification |
Subcellular location: | Cell membrane |
Predicted MW. / Observed MW. | 43 kDa / 43 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 1000-1: 2000 | brain, cerebral cortex |
IHC/IF | Mouse, Rat | 1: 1000-1: 2000 | cerebellum, hippocampus |
Background
GAP43 has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development, during axonal regeneration and is phosphorylated after long-term potentiation(LTP) and after learning (reference needed). This protein is considered a crucial component of the axon andpresynaptic terminal, its null mutation leading to death within days after birth due to axon pathfinding defects.
Images
| Western blot analysis of GAP43 (GB12095) at dilution of 1: 2000 |
| Immunohistochemistry analysis of paraffin-embedded mouse cerebellum using GAP43 (GB12095) at dilution of 1: 2000 |
| Immunohistochemistry analysis of paraffin-embedded rat spinal cord using GAP43 (GB12095) at dilution of 1: 2000 |
| Immunohistochemistry analysis of paraffin-embedded rat hippocampus using GAP43 (GB12095) at dilution of 1: 2000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |