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| Reactivity: | Mouse, Rat |
| Applications: | WB, ELISA |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Polyclonal antibody |
| Gene Name: | HtrA serine peptidase 1 |
| Gene Symbol: | HTRA1 |
| Synonyms: | L56; HtrA; ARMD7; ORF480; PRSS11; CARASIL; CADASIL2; HTRA1 |
| Gene ID: | 5654 |
| UniProt ID: | Q92743 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-160 of human HTRA1 (NP_002766.1). |
| Dilution: | WB 1:500-1:2000 |
| Purification Method: | Affinity purification |
| Concentration: | 0.84 mg/ml |
| Buffer: | PBS with 0.01% thimerosal, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
| Documents: | Manual-HTRA1 antibody |
Background
This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7.
Images
 | Western blot analysis of various lysates using HTRA1 Rabbit pAb (A11693) at 1:3000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s. |
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