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| Reactivity: | Human, Mouse |
| Applications: | IF/IC, ELISA |
| Host Species: | Rabbit |
| Clonality: | Polyclonal antibody |
| Gene Name: | jade family PHD finger 1 |
| Gene Symbol: | JADE1 |
| Synonyms: | PHF17; JADE1 |
| Gene ID: | 79960 |
| UniProt ID: | Q6IE81 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 210-509 of human JADE1 (NP_079176.2). |
| Dilution: | IF/IC 1:50-1:100 |
| Purification Method: | Affinity purification |
| Concentration: | 2.63 mg/ml |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
| Documents: | Manual-JADE1 antibody |
Background
Enables transcription coactivator activity. Involved in histone acetylation and negative regulation of canonical Wnt signaling pathway. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle. Located in several cellular components, including ciliary basal body; cytosol; and nuclear speck. Part of histone acetyltransferase complex.
Images
 | Immunofluorescence analysis of U2OS cells using JADE1 Rabbit pAb (A12579). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (AS007) at 1:500 dilution. Blue: DAPI for nuclear staining. |
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