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Recombinant Anti-MUC1/CD227 Mouse mAb (100 μl)
| Reactivity: | H |
| Applications: | IHC/IF |
| Host Species: | Mouse |
| Clonality: | Monoclonal |
| Gene Name: | Mucin-1 |
Synonyms: | ADMCKD, ADMCKD1, CD227, MCD, MCKD, MCKD1, PEM, PUM, PEMT, Episialin, EAM, CA 15-3 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human MUC1 |
Uniprot ID: | P15941 |
Isotype: | IgG1 |
Purity: | Affinity purification |
Subcellular location: | Cell membrane |
Product Usage Information
IHC/IF | Human | 1: 500-1: 1000 | kidney, breast cancer |
Background
The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.; The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.
Images
| Immunohistochemistry analysis of paraffin embedded human kidney using MUC1 (GB154938) at dilution of 1: 500 |
| Immunohistochemistry analysis of paraffin embedded human breast cancer using MUC1 (GB154938) at dilution of 1: 500 |
| Immunohistochemistry analysis of paraffin embedded human breast cancer using MUC1 (GB154938) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |