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Anti-Myeloperoxidase Mouse mAb (50 μl)
| Reactivity: | H |
| Applications: | IHC/IF |
| Host Species: | Mouse |
| Clonality: | Monoclonal |
| Gene Name: | Myeloperoxidase(MPO) |
Gene ID: | 4353 |
Immunogen: | Synthesized peptide derived from human Myeloperoxidase(MPO) |
Uniprot ID: | P05164 |
Source: | Mouse/IgG2a, Kappa |
Concentration: | 1 mg/ml |
Purity: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
Product Usage Information
IHC/IF | Human | 1: 200-1: 500 | tonsil |
Background
The MPO gene encodes myeloperoxidase, a lysosomal hemoprotein located in the azurophilic granules of polymorphonuclear (PMN) leukocytes and monocytes. In response to stimulation, MPO is activated into a transient intermediate with potent antimicrobial oxidizing abilities . The mRNA is translated into a single protein of 90 kDa, which displays enzymatic activity and undergoes proteolytic maturation into a heavy chain of 59 kDa and a light chain of 13.5 kDa; these subunits then dimerize into the mature tetramer and the mature MPO is a heterotetramer composed of two identical heavy chains and two identical light chains . The 24-kDa material had a map identical to that of 13.5 kDa subunit and represents a dimer of the 13.5 kDa subunit . Defects in MPO are the cause of myeloperoxidase deficiency (MPOD). It has 3 isoforms produced by alternative splicing. This antibody is specific to MPO.
Images
| Immunohistochemistry analysis of paraffin embedded human tonsil using Myeloperoxidase (GB14115) at dilution of 1: 200 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |