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| Reactivity: | Human |
| Applications: | IHC, ELISA |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Polyclonal antibody |
| Gene Name: | BCL2 like 11 |
| Gene Symbol: | BCL2L11 |
| Synonyms: | BAM; BIM; BOD; Bim |
| Gene ID: | 10018 |
| UniProt ID: | O43521 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-130 of human Bim (NP_619527.1). |
| Dilution: | IHC 1:50-1:100 |
| Purification Method: | Affinity purification |
| Concentration: | 3.8 mg/ml |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
| Documents: | Manual-BCL2L11 antibody |
Background
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.
Images
 | Immunohistochemistry analysis of paraffin-embedded Human tonsil using Bim Rabbit pAb (A12554) at dilution of 1:100 (40x lens). Microwave antigen retrieval performed with 0.01M PBS Buffer (pH 7.2) prior to IHC staining. |
 | Immunohistochemistry analysis of paraffin-embedded Human liver using Bim Rabbit pAb (A12554) at dilution of 1:100 (40x lens). Microwave antigen retrieval performed with 0.01M PBS Buffer (pH 7.2) prior to IHC staining. |
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