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Biotin Rabbit anti-Human CD4 mAb (100 T)
| Reactivity: | Human |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | Biotin |
| Gene Name: | CD4 molecule |
| Gene Symbol: | CD4 |
| Synonyms: | T4; IMD79; Leu-3; OKT4D; CD4mut |
| Gene ID: | 920 |
| UniProt ID: | P01730 |
| Immunogen: | Recombinant protein of human CD4. |
| Dilution: | FC,5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.04 mg/mL |
| Buffer: | PBS with 0.09% Sodium azide,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-CD4 Antibody |
Background
This gene encodes the CD4 membrane glycoprotein of T lymphocytes. The CD4 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class II MHC molecules. The CD4 antigen is also a primary receptor for entry of the human immunodeficiency virus through interactions with the HIV Env gp120 subunit. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, granulocytes, as well as in various regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene.
Images
 | Flow cytometry: 1×10^6 PC-3 cells (negative control,left) and Human PBMC (Lymphocytes,right) were surface-stained with Biotin Rabbit anti-Human CD4 mAb (A27377,5 μl/Test,orange line) or Biotin Rabbit IgG isotype control (A25626,5 μl/Test,blue line), followed by ABflo® 488 Streptavidin staining. Non-fluorescently stained cells were used as blank control (red line). |
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