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| Reactivity: | Mouse |
| Applications: | FC |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | Unconjugated |
| Gene Name: | interleukin 6 signal transducer |
| Gene Symbol: | Il6st |
| Synonyms: | CD130; gp130; D13Ertd699e; 5133400A03Rik |
| Gene ID: | 16195 |
| UniProt ID: | Q00560 |
| Clone ID: | 7L2L10 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-617 of mouse CD130/gp130 (NP_034690.3). |
| Dilution: | FC,1:100 - 1:500 |
| Purification Method: | Affinity purification |
| Concentration: | 1.2 mg/mL |
| Buffer: | PBS with 0.05% proclin300,0.05% BSA,50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-Il6st antibody |
Background
Contributes to interleukin-11 binding activity and interleukin-11 receptor activity. Involved in interleukin-6-mediated signaling pathway; intestinal epithelial cell development; and positive regulation of Notch signaling pathway. Acts upstream of or within several processes, including glycogen metabolic process; positive regulation of astrocyte differentiation; and regulation of Notch signaling pathway. Located in dendrite; external side of plasma membrane; and neuronal cell body. Is expressed in several structures, including alimentary system; brain; early conceptus; immune system; and reproductive system. Used to study rheumatoid arthritis and stomach cancer. Human ortholog(s) of this gene implicated in arteriosclerosis; hyper IgE recurrent infection syndrome 4; and hyperandrogenism. Orthologous to human IL6ST (interleukin 6 cytokine family signal transducer).
Images
 | Flow cytometry: 1×10^6 Neuro-2a cells (Low Expression,left) and NIH/3T3 cells (right) were surface-stained with CD130/gp130 Rabbit mAb (A24991,2 μg/mL,orange line) or ABflo® 647 Rabbit IgG isotype control (A22070,5 μl/Test,blue line), followed by Alexa Fluor® 647 conjugated goat anti-rabbit pAb staining. Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 NIH/3T3 cells were surface-stained with ABflo® 647 Rabbit IgG isotype control (A22070,5 μl/Test,left) or CD130/gp130 Rabbit mAb (A24991,2 μg/mL,right). |
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