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| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | CD146 rabbit polyclonal antibody |
Gene Name: | Cell surface glycoprotein MUC18 |
Synonyms: | Gicerin, Melanoma cell adhesion molecule, Melanoma-associated antigen MUC18, CD146, Muc18, Mcam, MelCAM, Sendo1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse CD146 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 72 kDa |
Observed MW. | 120 kDa |
Uniprot ID: | P43121, Q8R2Y2, Q9EPF2 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | blood vessels, uterus, stomach |
Background
MCAM is an immunoglobulin super family member originally described as a cell surface adhesion protein and marker of the progression and metastasis of melanoma . Expression of MCAM protein is seen in vascular endothelial cells, activated T lymphocytes, smooth muscle, and bone marrow stromal cells. Research studies demonstrate increased MCAM expression in endothelial cells from angiogenesis-related disorders, including inflammatorybowel disease, Crohn’s disease, rheumatoid arthritis, tumors, and chronic renal failure. MCAM-expressing human mesenchymal stromal cells in the hematopoietic microenvironment are responsible for maintaining the self-renewal of hematopoietic stem and progenitor cells through direct contact between hMSC and those cells .
Images
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Western blot analysis of CD146 (GB11955) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |