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| Reactivity: | M,R & H,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Complement receptor type 1 |
Synonyms: | C3b/C4b receptor, CD35, CR1, C3BR, C3 binding protein, C4BR , Knops blood group antigen |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human CD35 |
Uniprot ID: | P17927 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Secreted |
Predicted MW. / Observed MW. | 224 kDa / 224 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 500-1: 1000 | spleen+LPS, lung+LPS, kidney+LPS |
IHC/IF | Human, Rat | 1: 650-1: 1300 | liver, nephritis, spleen |
Background
This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement.
Images
| Western blot analysis of CD35 (GB112007) at dilution of 1: 1000 |
| Immunofluorescence analysis of paraffin embedded human liver using CD35 (GB112007) at dilution of 1: 650 |
| Immunofluorescence analysis of paraffin embedded rat nephritis using CD35 (GB112007) at dilution of 1: 650 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |