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| Reactivity: | Human |
| Applications: | WB, ELISA |
| Host Species: | Rabbit |
| Clonality: | Polyclonal antibody |
| Gene Name: | cell division cycle 73 |
| Gene Symbol: | CDC73 |
| Synonyms: | HYX; FIHP; HPTJT; HRPT1; HRPT2; C1orf28; HRPT2 / CDC73 |
| Gene ID: | 79577 |
| UniProt ID: | Q6P1J9 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 435-505 of human HRPT2 / CDC73 (Q6P1J9). |
| Dilution: | WB 1:500-1:2000 |
| Purification Method: | Affinity purification |
| Concentration: | 0.86mg/mL |
| Buffer: | PBS with 0.01% thimerosal, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-CDC73 antibody |
Background
This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma.
Images
 | Western blot analysis of lysates from mouse testis, using HRPT2 / CDC73 Rabbit pAb (A0636). Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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