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| Reactivity: | Human, Mouse |
| Applications: | WB, IP, ELISA |
| Host Species: | Rabbit |
| Clonality: | Polyclonal antibody |
| Gene Name: | cytoplasmic FMR1 interacting protein 1 |
| Gene Symbol: | CYFIP1 |
| Synonyms: | SHYC; SRA1; SRA-1; P140SRA-1; CYFIP1 |
| Gene ID: | 23191 |
| UniProt ID: | Q7L576 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human CYFIP1 (NP_055423.1). |
| Dilution: | WB 1:1000-1:2000 |
| Purification Method: | Affinity purification |
| Concentration: | 0.77 mg/ml |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-CYFIP1 antibody |
Background
This gene encodes a protein that regulates cytoskeletal dynamics and protein translation. The encoded protein is a component of the WAVE regulatory complex (WRC), which promotes actin polymerization. This protein also interacts with the synaptic functional regulator FMR1 protein and translation initiation factor 4E to inhibit protein translation. A large chromosomal deletion including this gene is associated with increased risk of schizophrenia and epilepsy in human patients. Reduced expression of this gene has been observed in various human cancers and the encoded protein may inhibit tumor invasion.
Images
 | Western blot analysis of various lysates using CYFIP1 Rabbit pAb (A10291) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunoprecipitation analysis of 300 μg extracts of BT-474 cells using 3 μg CYFIP1 antibody (A10291). Western blot was performed from the immunoprecipitate using CYFIP1 antibody (A10291) at a dilution of 1:500. |
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