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| Reactivity: | Human |
| Applications: | IHC, IF/IC, ELISA |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Polyclonal antibody |
| Gene Name: | cytochrome P450 family 11 subfamily B member 1 |
| Gene Symbol: | CYP11B1 |
| Synonyms: | FHI; CPN1; CYP11B; P450C11; CYP11B1 |
| Gene ID: | 1584 |
| UniProt ID: | P15538 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 234-503 of human CYP11B1 (NP_000488.3). |
| Dilution: | IHC 1:100-1:500; IF/IC 1:2000-1:8000 |
| Purification Method: | Affinity purification |
| Concentration: | 2.55 mg/ml |
| Buffer: | Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
| Storage: | Store at -20°C. Avoid freeze/thaw cycles. |
| Documents: | Manual-CYP11B1 antibody |
Background
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of progesterone to cortisol in the adrenal cortex. Mutations in this gene cause congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. Transcript variants encoding different isoforms have been noted for this gene.
Images
 | Immunohistochemistry analysis of paraffin-embedded Human adrenal gland tissue using CYP11B1 Rabbit pAb (A15046) at a dilution of 1:4000 (40x lens). High pressure antigen retrieval performed with 0.01M Tris-EDTA Buffer (pH 9.0) prior to IHC staining. |
 | Immunofluorescence analysis of U2OS cells using CYP11B1 Rabbit pAb (A15046) at dilution of 1:100. Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (AS007) at 1:500 dilution. Blue: DAPI for nuclear staining. |
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