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Anti-Citrate synthetase Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Citrate synthetase rabbit polyclonal antibody |
Gene Name: | Citrate synthase, mitochondrial |
Synonyms: | Citrate (Si)-synthase, CS, ACL, ACLY, ATP citrate (pro S ) lyase, ATP citrate lyase, ATP Citrate synthase, ATPCL, Citrate cleavage enzyme, CLATP, EC 2.3.3, EC 2.3.3.1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human Citrate synthetase |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 52 kDa |
Observed MW. | 45 kDa |
Uniprot ID: | Q9CZU6, Q8VHF5 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Mouse, Rat | 1: 1000-1: 1500 | skeletal muscle, heart, brain |
Background
ACLY(ATP-citrate synthase) is also named as ACL. It is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA. ACLY serves as not only a target in oxygenated cells for suppression of lipid synthesis and histone acetylation, but also as a susceptible target in hypoxic cells to restore inhibition of glycolysis. In nonsmall cell lung carcinoma and hepatocellular carcinoma, ACLY is overexpressed compared with normal parenchyma suggesting that ACLY may represent a common target among highly malignant tumors.
Images
| Western blot analysis of Citrate synthase (GB111883) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |