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Anti-DMGDH Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | DMGDH rabbit polyclonal antibody |
Gene Name: | Dimethylglycine dehydrogenase |
Synonyms: | ME2GLYDH, mitochondrial, Dmgdh, Dimethylglycine dehydrogenase |
Immunogen: | Recombinantproteincorrespondingto Mouse DMGDH |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 97 kDa |
Observed MW. | 97 kDa |
Uniprot ID: | Q9UI17 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human | 1: 500-1: 1000 | HepG2, MCF-7, 293T |
Background
This gene encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme is found as a monomer in the mitochondrial matrix, and uses flavin adenine dinucleotide and folate as cofactors. Mutation in this gene causes dimethylglycine dehydrogenase deficiency, characterized by a fishlike body odor, chronic muscle fatigue, and elevated levels of the muscle form of creatine kinase in serum. Alternative splicing results in multiple transcript variants.
Images
| Western blot analysis of DMGDH (GB111709) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |